Cell differentiation: When DNA met Sall4 with Raphael Pantier and Kashyap Chhatbar
From Liz Gaberdiel
Have you ever wondered what neglected regions of the genome do? In this episode we hear about the search for AT rich region binding proteins.
Jack Suitor talks to Raphael Pantier and Kashyap Chhatbar from the Bird lab at the University of Edinburgh about their work on the DNA binding protein Sall4. They discover that Sall4 binds to AT rich regions which affects large scale gene expressions and enables differentiation.
Sall4 could help time cellular differentiation as part of embryonic development and is therefore implicated in developmental disease. By getting more insight into proteins that bind AT rich regions we could learn more about the cause of some diseases.