Introduction to Mixed Models
Training session with Dr Helen Brown, Senior Statistician, at The Roslin Institute, March 2016.
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These training sessions were given to staff and research students at the Roslin Institute. The material is also used for the Animal Biosciences MSc course taught at the Institute.
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*Recommended YouTube playback settings for the best viewing experience:  1080p HD
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Content:
Example 1:Biological & Technical Replicates
- Experiments to compare responses between groups 
- Groups: Human TLR5, Bovine TLR5
- 6 experiments with 3 replicates per group
- Variation between: Technical replicates & experiments

Consider 0.5 ng/ml Concentration (Human and Bovine only)
What is the combined ‘species’ (human vs bovine) effect?
Model:
What is the combined result?

Mixed model with different group variances

Now consider 5ng/ml Concentration
What is the combined result?

Supposing some values are missing…
What is the combined result?