Phylogenetics and Phylogeography(Advanced Analytical Methods)
Lecture by Dr Sam Lycett, filmed at The Roslin Institute, March 2015.
(Recommended YouTube playback settings for the best viewing experience: 1080p HD)
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Content:
a.Population Models
--EAST uses coalescent models from population genetics
--Rate of Coalescence depends on effective population size
--Distribution of branch lengths depends on population size model
--Exponential growth model applicable to epidemic situations
--TMRCA (origin time) and growth rate of epidemic can be calculated from sequence data