A Chat About How to Characterize Cell Structural Lamin-A Proteins with Dr Alex Makarov
From Hanna Peach
In this episode, Chris sits down with Dr Alex Makarov who recently completed a PhD in Eric Schirmer's lab in the Wellcome Centre for Cell Biology at the University of Edinburgh. His research focused on Lamin A proteins, an important structural protein which give cells their flexibility and shape. Dr Makarov recently published his novel work on the alternative methods to characterise the structure of flexible Lamin A proteins, namely SILAC cross-linking mass spectrometry.
Lamin-A function is so important that mutations leading to alterations of this protein's structure are linked to 13 distinct human syndromes ranging from cardiomyopathy to lipodystrophy and progeria.
Here is the publication DOI: https://doi.org/10.1038/s41467-019-11063-6
Listen until the end to hear our end segment on Veganuary and the future of food.