Dr Henry McSorley - IL-33 suppressors from a helminth parasite: potential for treaments in asthma
From Yuhua Lei on May 18th, 2020
Infection Medicine Seminar Series
18th May 2020
Dr Henry McSorley - Principal Investigator and joint Deputy Head of the Division of Cell Signalling and Immunology, University of Dundee
The IL-33 pathway is strongly implicated in allergic diseases, and in resistance to parasitic nematodes. We have discovered that the parasitic nematode Heligmosomoides polygyrus secretes several immunomodulatory families of proteins, including HpARI, which binds and blocks IL-33, and HpBARI, which binds and blocks the IL-33 receptor (ST2). Both HpARI and HpBARI are capable of suppressing pathology in mouse models of allergic asthma. These proteins are also active against human IL-33/ST2, and so have potential for development as treatments for human allergic diseases.